Kolonin 2004 - Reversal of Obesity by Targeted Ablation of Adipose Tissue

Nature Medicine·June 1, 2004

Mikhail G. Kolonin, Renata Pasqualini, Wadih Arap

Summary

Foundational adipose-vasculature targeting paper behind the adipotide concept, showing weight reduction through targeted ablation of adipose tissue.

Study Details

Study Design

Mouse proof-of-concept study using vascular homing peptide strategy

Indication

Obesity and adipose tissue targeting

Intervention

Proapoptotic peptide targeted to white fat vasculature

Species

Animal

Risk of Bias Assessment

Preclinical mouse study