Belchetz 1978 - Hypophysial Responses to Continuous and Intermittent GnRH Stimulation

Science·July 1, 1978

P. E. Belchetz, T. M. Plant, Y. Nakayama, E. J. Keogh, E. Knobil

Summary

Classic study showing that intermittent GnRH stimulation is required for sustained gonadotropin secretion, foundational for gonadorelin/GnRH physiology.

Study Details

Study Design

Physiological endocrine study

Indication

GnRH pulsatility and pituitary gonadotropin release

Intervention

Intermittent versus continuous GnRH / gonadorelin stimulation

Species

Animal

Risk of Bias Assessment

Foundational physiology; not modern therapeutic RCT