Lee 2015 — MOTS-c Discovery Paper

Cell Metabolism·March 3, 2015

Changhan Lee, Jennifer Zeng, Brian G. Drew, Tamer Sallam, Alejandro Martin-Montalvo, Junxiang Wan, Su-Jeong Kim, Hemal Mehta, Andrea L. Hevener, Rafael de Cabo, Pinchas Cohen

Summary

Discovery of MOTS-c, a mitochondrial-derived peptide that regulates insulin sensitivity and metabolic homeostasis via AMPK. Primary target is skeletal muscle.

Study Details

Study Design

Discovery and characterization study

Indication

Metabolic homeostasis, insulin sensitivity

Intervention

MOTS-c peptide

Species

Mouse

Risk of Bias Assessment

Cohen laboratory